Besides manufacturing clinical grade stem cells, SBS pursues research and development in the domain of stem cells in order to create new cell therapy based modalities for human medical use. Adipose tissue derived stem cells (ADSCs) are self renewing cells that can differentiate to many other cell types. This makes ADSCs attractive starting material for developing cell based treatments for regenerative medicine applications. After transplantation the engrafted multipotent stem cells differentiate into different cell types and regenerate the damaged tissue. Alternatively, some secretomes of transplanted stem cells stimulates the endogenous stem cells that repair the damaged cells. This signaling from one cell to another is called the paracrine effect; the action of the secretion of one kind of cell on another kind. In fact paracrine effect acts by regenerating the damaged host tissue without direct engrafting of the the transplanted cells. Many different cell types, including adipose tissue derived stem cells, can invoke a paracrine response that result in activation of host stem cells after transplantation.
Extracellular Vesicles (EVs) are small cargo-carrying vesicles released by cells to the extracellular space, which can be utilized and loaded for specific purpose by preconditioning the stem cells, offering great diagnostic and therapeutic potential.
Exosomes are tiny vesicles released by cells that can deliver drugs and help repair or regulate the body. They are safe, stable, and can be stored for use as ready-made treatments.
